Chronic Myeloid Leukemia Pathway

Preferred Label : Chronic Myeloid Leukemia Pathway;

NCIt synonyms : CML Pathway;

NCIt related terms : Chronic myeloid leukemia;

Alternative definition : KEGG: Chronic myelogenous leukaemia (CML) is a biphasic disease, initiated by expression of the BCR/ABL fusion gene product in self-renewing, haematopoietic stem cells (HSCs). HSCs can differentiate into common myeloid progenitors (CMPs), which then differentiate into granulocyte/macrophage progenitors (GMPs). HSCs can also differentiate into common lymphoid progenitors (CLPs), which are the progenitors of lymphocytes such as T cells and B cells. The initial chronic phase of CML (CML-CP) is characterized by a massive expansion of the granulocytic-cell series. Acquisition of additional genetic mutations beyond expression of BCR/ABL causes the progression of CML from chronic phase to blast phase (CML-BP), characterized by an accumulation of myeloid or lymphoid blast cells.;

KEGG ID : hsa05220;

Details

Origin ID

C91465;

UMLS CUI

C2984277;

Automatic exact mappings (from CISMeF team)
- Chronic myelogenous leukemia [HPO term]
- Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype (morphologic abnormality) [SNOMED CT concept]
- Chronic myeloid leukemia [MedDRA LLT]
- Chronic myeloid leukemia [ICD-9 code]
- Chronic myeloid leukemia (disorder) [SNOMED CT concept]
- Leukemia, chronic myeloid [OMIM Phenotype]
- Myeloid leukemia, chronic [MedDRA LLT]
- Myeloid leukemia, chronic [ICD-9 code]
- chronic myeloid leukemia [SNOMED Notion]
- chronic myeloid leukemia [DO Concept]
- chronic myeloid leukemia [MedlinePlus Topic]
- leukemia, myelogenous, chronic, bcr-abl positive [MeSH Descriptor]
See also inter- (CISMeF)
- Chronic myeloid leukemia [ORDO Disease]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Adapter Molecule crk [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Breakpoint Cluster Region Protein [NCIt concept]
- C-Terminal-Binding Protein 1 [NCIt concept]
- Crk-Like Protein [NCIt concept]
- Cyclin-Dependent Kinase 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-B [NCIt concept]
- E3 Ubiquitin-Protein Ligase CBL-C [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- GRB2-Associated-Binding Protein 2 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Histone Deacetylase 1 [NCIt concept]
- Histone Deacetylase 2 [NCIt concept]
- Histone-Lysine N-Methyltransferase MECOM [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- MECOM Protein Isoform Evi-1a [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Runt-Related Transcription Factor 1 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- SHC-Transforming Protein 2 [NCIt concept]
- SHC-Transforming Protein 3 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Signal Transducer and Activator of Transcription 5A [NCIt concept]
- Signal Transducer and Activator of Transcription 5B [NCIt concept]
- Son of Sevenless Homolog 1 [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transcription Factor E2F1 [NCIt concept]
- Transcription Factor E2F2 [NCIt concept]
- Transcription Factor E2F3 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tyrosine-Protein Kinase ABL1 [NCIt concept]
- Tyrosine-Protein Phosphatase Non-Receptor Type 11 [NCIt concept]
pathway_has_gene_element
- ABL1 wt Allele [NCIt concept]
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BCR wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CBL wt Allele [NCIt concept]
- CBLB wt Allele [NCIt concept]
- CBLC wt Allele [NCIt concept]
- CDK6 wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CRK wt Allele [NCIt concept]
- CRKL wt Allele [NCIt concept]
- CTBP1 wt Allele [NCIt concept]
- E2F1 wt Allele [NCIt concept]
- E2F2 wt Allele [NCIt concept]
- E2F3 wt Allele [NCIt concept]
- GAB2 wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HDAC1 wt Allele [NCIt concept]
- HDAC2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MECOM wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PTPN11 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- RUNX1 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SHC2 wt Allele [NCIt concept]
- SHC3 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SOS1 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- STAT5A wt Allele [NCIt concept]
- STAT5B wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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