Zinc Finger and BTB Domain-Containing Protein 16

Preferred Label : Zinc Finger and BTB Domain-Containing Protein 16;

NCIt synonyms : Promyelocytic Leukemia Zinc Finger Protein; Zinc Finger Protein-145; ZBTB16; Zinc Finger Protein PLZF; Zinc Finger Protein 145; ZNF145;

NCIt related terms : Zinc Finger and BTB Domain Containing Protein 16;

NCIt definition : Zinc finger and BTB domain-containing protein 16 (673 aa, 74 kDa) is encoded by the human ZBTB16 gene. This protein is involved in both myeloid differentiation and transcriptional regulation.;

NCIt note : ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression.;

Details

Origin ID

C17918;

UMLS CUI

C0294292;

OMIM relation
- Zinc finger- and btb domain-containing protein 16 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ZBTB16 protein, human [MeSH concept]
- ZBTB16 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
- ZBTB16 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- BTB/POZ Domain [NCIt concept]
- C2H2 Zinc Finger [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Map Kinase Inactivation of SMRT Corepressor Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Myelopoiesis [NCIt concept]
- Nervous System Development [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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