Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA - CISMeF
Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARANCIt concept
Preferred Label : Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA;
NCIt synonyms : Acute Promyelocytic Leukemia; FAB M3; AML with t(15;17)(q24.1;q21.2); APML - Acute promyelocytic leukemia; Acute Promyelocytic Leukemia with PML::RARA; Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML::RARA; Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA Fusion; Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML::RARA Fusion;
NCIt related terms : promyelocytic leukemia; Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML/RARA; Acute promyelocytic leukaemia, t(15;17)(q22;q11-12); APML; Acute Promyelocytic Leukemia with PML-RARA; Acute promyelocytic leukaemia, PML-RAR-alpha; Acute Promyelocytic Leukemia with t(15;17)(q22;q12); PML-RARA; APL; M3; M3 OR Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA;
NCIt definition : An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is
characterized by the PML-RARA fusion. There are two variants: the typical and microgranular
variant. This AML is particularly sensitive to treatment with all trans-retinoic acid
and has a favorable prognosis. (WHO);
Alternative definition : NCI-GLOSS: An aggressive (fast-growing) type of acute myeloid leukemia in which there
are too many immature blood-forming cells in the blood and bone marrow. It is usually
marked by an exchange of parts of chromosomes 15 and 17.; NICHD: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia
(AML), and it is treated differently than other types of AML because of its marked
sensitivity to differentiating effects of all trans-retinoic acid. APL is characterized
by a severe coagulopathy which may be present at diagnosis. APL occurs in 7 % of children
with AML.;
Neoplastic status : Malignant;
ICD-O code : 9866/3;
Codes from synonyms : CDR0000444957; CDR0000522912; 10001019; CDR0000046159;