Acute promyelocytic leukemia

Preferred Label : Acute promyelocytic leukemia;

Symbol : APL;

CISMeF acronym : APL;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Leukemia, acute promyelocytic;

Description : Acute promyelocytic leukemia (APL) is associated with 2 cardinal features: a granulocytic differentiation block and reciprocal and balanced translocations that always involve rearrangement of the RARA gene (180240). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene (102578) and represents more than 98% of APL (Vitoux et al., 2007).;

Prefixed ID : #612376;

Details

Origin ID

612376;

UMLS CUI

C0023487;

Automatic exact mappings (from CISMeF team)
- Acquired Progressive Lymphangioma [NCIt concept]
- Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.1), PML-RARA [ICD-11 More detail]
- platelet aggregation inhibitors [MeSH Descriptor]
Currated CISMeF NLP mapping
- Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA [NCIt concept]
- Acute promyelocytic leukaemia [ICD-10 Sub-category (who)]
- Acute promyelocytic leukaemia [MedDRA Preferred Term]
- Acute promyelocytic leukemia [PASCAL descriptor]
- Acute promyelocytic leukemia [ICD-10 Sub-category]
- Acute promyelocytic leukemia [HPO term]
- Acute promyelocytic leukemia [ORDO Disease]
- Acute promyelocytic leukemia [MedDRA LLT]
- Acute promyelocytic leukemia [ICD-9 code]
- Acute promyelocytic leukemia with PML::RARA fusion (morphologic abnormality) [SNOMED CT concept]
- Acute promyelocytic leukemia, FAB M3 (disorder) [SNOMED CT concept]
- acute promyelocytic leukemia [DO Concept]
- acute promyelocytic leukemia [SNOMED Notion]
- leukemia, promyelocytic, acute [MeSH Descriptor]
- leukemia, promyelocytic, acute [MeSH concept]
- promyelocytic leukemia [Disease (Nov.)]
DO Cross reference
- acute promyelocytic leukemia [DO Concept]
Genes related to phenotype
- Nuclear mitotic apparatus protein 1 [OMIM gene]
HPO term(s)
- Abnormal granulocytopoietic cell morphology [HPO term]
- Acute promyelocytic leukemia [HPO term]
- Somatic mutation [HPO term]
ORDO concept(s)
- Acute promyelocytic leukemia [ORDO Disease]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA [NCIt concept]
- Acute promyelocytic leukaemia [ICD-10 Sub-category (who)]
- Acute promyelocytic leukaemia [MedDRA Preferred Term]
- Acute promyelocytic leukemia [ORDO Disease]
- Acute promyelocytic leukemia [MedDRA LLT]
- Acute promyelocytic leukemia [ICD-10 Sub-category]
- Acute promyelocytic leukemia [HPO term]
- Acute promyelocytic leukemia [PASCAL descriptor]
- Acute promyelocytic leukemia with PML::RARA fusion (morphologic abnormality) [SNOMED CT concept]
- Acute promyelocytic leukemia, FAB M3 (disorder) [SNOMED CT concept]
- acute promyelocytic leukemia [SNOMED Notion]
- acute promyelocytic leukemia [DO Concept]
- leukemia, promyelocytic, acute [MeSH Descriptor]
- leukemia, promyelocytic, acute [MeSH concept]
- promyelocytic leukemia [Disease (Nov.)]

Keyword's position in hierarchy(ies) :

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