" /> PML/RARA Fusion Gene - CISMeF





Preferred Label : PML/RARA Fusion Gene;

NCIt synonyms : PML-RARA Fusion Gene; PML-RAR Alpha Fusion Gene; PML-RAR; PML::RARA Fusion Gene;

NCIt definition : A fusion gene that results from a chromosomal translocation t(15;17)(q22;q21) which fuses the first 3 exons of the PML gene with the last 7 exons of the RARA gene. This fusion is associated with acute promyelocytic leukemia. Three transcript variants are possible based on the three breakpoint clusters in the PML gene.;

NCIt note : The translocation, well known as t(15;17)(q22;q21) or t(15;17)(q22;q12), should be re-named t(15;17)(q24;q21), since the PML gene is located in the vicinity of 15q24, and the RARA gene is located in the vicinity of 17q21. (Atlas of Genetics and Cytogenetics in Oncology and Haematology);

GenBank Accession Number : M73779;

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14/05/2024


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