PML/RARA Fusion Protein

Preferred Label : PML/RARA Fusion Protein;

NCIt synonyms : PML-RAR Alpha Fusion Protein; PML-RARalpha Fusion Protein; Inducer of Acute Promyelocytic Leukemia; PML-RARA Fusion Protein; Protein PML/Retinoic Acid Receptor Alpha Fusion Protein; PML-RAR Protein; PML-RAR Alpha; PML::RARA Fusion Protein;

NCIt definition : A fusion protein (797 aa, 106 kDa) that is encoded by the human PML/RARA fusion gene. This protein contains the B-box and the RING-finger domain from protein PML and the DNA-binding domain, ligand binding domain and coactivator recognition site from the retinoic acid receptor alpha protein.;

NCIt note : PML-RARA fusion protein may cause aberrant signaling of pathways that are regulated by retinoid molecules.;

Details

Origin ID

C53622;

UMLS CUI

C1709412;

Automatic exact mappings (from CISMeF team)
- Acute promyelocytic leukemia, inducer of [OMIM gene]
- leukemia, promyelocytic, acute [MeSH Descriptor]
OMIM relation
- Acute promyelocytic leukemia, inducer of [OMIM gene]
See also inter- (CISMeF)
- Acute promyelocytic leukemia [ORDO Disease]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- PML/RARA Fusion Gene [NCIt concept]
is_target
- Arsenic Trioxide [NCIt concept]
related_to_genetic_biomarker
- PML Gene [NCIt concept]
- RARA Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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