Preferred Label : Protein CBFA2T1;
NCIt synonyms : Eight Twenty One Protein; Cyclin D Related Protein; Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8B; CBFA2T1; ETO; Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8A; Cyclin D-Related; Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8C; Core-Binding Factor, Alpha Subunit 2, Translocated to 1; MTG8 Protein; Zinc Finger MYND Domain Containing Protein 2; Cyclin-D-Related Protein; ETO Protein; Zinc Finger MYND Domain-Containing Protein 2; Protein ETO; Protein MTG8;
NCIt definition : Protein CBFA2T1 (604 aa, 68 kDa) is encoded by the human RUNX1T1 gene. This protein
plays a role in the regulation of gene transcription.;
NCIt note : ETO Protein is a putative MYND zinc finger transcription factor expressed as multiple
isoforms in brain, heart, lung, pituitary, skeletal muscle, pancreas, placenta, testis,
and ovary. MTG8B and MTG8C variants have distinct N-termini. One frameshifted MTG8
variant lacks C-terminal zinc fingers, a P/S/T-rich domain, and a coiled-coil structure.
Associated with NCOR/HDAC, this protein may repress transcription and differentiation
in hematopoietic precursors. (from LocusLink, Swiss-Prot, OMIM);
Origin ID : C18320;
UMLS CUI : C0218234;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_organism_source
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
