Zinc-Binding, DNA-Binding Motif

Preferred Label : Zinc-Binding, DNA-Binding Motif;

NCIt synonyms : Zinc Finger Domain; Zinc Finger; Zinc-Binding DNA-Binding Motif;

NCIt definition : Zinc-binding, DNA-binding motifs in proteins contain amino acids that are folded into a single DNA-binding structural unit around a zinc atom.;

NCIt note : The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2 is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heterodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA.;

Details

Origin ID

C13427;

UMLS CUI

C0080347;

Automatic exact mappings (from CISMeF team)
- CXXC finger protein 1 [HGNC gene]
- DBF4-CDC7 kinase regulatory subunit [HGNC gene]
- DBF4B-CDC7 kinase regulatory subunit [HGNC gene]
- DNA topoisomerase III alpha [HGNC gene]
- ERI1 exoribonuclease family member 2 [HGNC gene]
- NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase [HGNC gene]
- SWIM-type zinc finger 7 associated protein 1 [HGNC gene]
- aprataxin and PNKP like factor [HGNC gene]
- apurinic/apyrimidinic endodeoxyribonuclease 2 [HGNC gene]
- immunoglobulin mu DNA binding protein 2 [HGNC gene]
- nei like DNA glycosylase 3 [HGNC gene]
- phosphoinositide kinase, FYVE-type zinc finger containing [HGNC gene]
- protein inhibitor of activated STAT 1 [HGNC gene]
- protein inhibitor of activated STAT 2 [HGNC gene]
- protein inhibitor of activated STAT 3 [HGNC gene]
- protein inhibitor of activated STAT 4 [HGNC gene]
- receptor transporter protein 1 [HGNC gene]
- receptor transporter protein 2 [HGNC gene]
- receptor transporter protein 3 [HGNC gene]
- receptor transporter protein 4 [HGNC gene]
- receptor transporter protein 5 (putative) [HGNC gene]
- ring finger and CHY zinc finger domain containing 1 [HGNC gene]
- thyroid hormone receptor interactor 4 [HGNC gene]
- transcription termination factor 2 [HGNC gene]
- zinc finger CCHC-type containing 24 [HGNC gene]
- zinc finger CCHC-type containing 4 [HGNC gene]
- zinc finger MYM-type containing 3 [HGNC gene]
- zinc finger MYM-type containing 6 [HGNC gene]
- zinc finger protein 276 [HGNC gene]
- zinc finger protein 664 [HGNC gene]
- zygote arrest 1 [HGNC gene]
- zygote arrest 1 like [HGNC gene]
Currated CISMeF NLP mapping
- zinc fingers [MeSH Descriptor]
- zinc fingers [MeSH concept]
Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
UMLS correspondences (same concept)
- zinc fingers [MeSH concept]
- zinc fingers [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- CXXC-Type Zinc Finger Protein 5 [NCIt concept]
- DNA Repair Protein Complementing XP-A Cells [NCIt concept]
- Methyl-CpG-Binding Domain Protein 1 [NCIt concept]
- Methylcytosine Dioxygenase TET3 [NCIt concept]
- Protein CBFA2T1 [NCIt concept]
- Tripartite Motif-Containing Protein 29 [NCIt concept]
- Zinc Finger Protein 40 [NCIt concept]
- Zinc Finger Ran-Binding Domain-Containing Protein 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients