Methyl-CpG-Binding Domain Protein 1

Preferred Label : Methyl-CpG-Binding Domain Protein 1;

NCIt synonyms : Methyl-CpG-Binding Protein MBD1; Protein Containing Methyl-CpG-Binding Domain 1; CXXC Finger Protein 3; MBD1; CXXC-Type Zinc Finger Protein 3; Methyl-CpG Binding Domain Protein 1;

NCIt definition : Methyl-CpG-binding domain protein 1 (605 aa, 67 kDa) is encoded by the human MBD1 gene. This protein plays a role in the repression of gene expression.;

NCIt note : Methyl-CpG-binding domain protein 1 specifically binds to CpG islands in promoters where position 5 of the cytosine is methylated. (UniProt);

Details

Origin ID

C148504;

UMLS CUI

C0911529;

Automatic exact mappings (from CISMeF team)
- Dipeptidase 1 [OMIM gene]
- Methyl-cpg-binding domain protein 1 [OMIM gene]
- methyl-CpG binding domain protein 1 [HGNC gene]
OMIM relation
- Methyl-cpg-binding domain protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MBD1 protein, human [MeSH concept]
- MBD1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MBD1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- DNA Binding Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- Proline-Rich Domain [NCIt concept]
- Zinc-Binding, DNA-Binding Motif [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients