Proline-Rich Domain

Preferred Label : Proline-Rich Domain;

NCIt synonyms : Proline-Rich Region; Pro-Rich; Proline Rich Region; Proline Rich Domain;

NCIt definition : Proline-Rich Domains may be involved in heterotypic protein-protein interactions in signal transduction or other pathways. Found in signaling and structural proteins, WW domains are composed of approximately 40 amino acids folded as a stable, triple stranded beta-sheet that recognize proline-rich sequences. Some WW domains show a remarkable similarity to SH3 domains, which also appear to recognize some proline-rich sequences. Ena/VASP (Drosophila Enabled/Vasodilator-Stimulated Phosphoprotein) Family members regulate actin filament assembly, often through association with binding partners that display a proline-rich FPPPP motif. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. (NCI);

Details

Origin ID

C14106;

UMLS CUI

C1514490;

Semantic type(s)
- Amino Acid Sequence [UMLS semantic type]
is_structural_domain_or_motif_of_gene_product
- 2'-5'-Oligoadenylate Synthase 2 [NCIt concept]
- AP-2 Complex Subunit Beta [NCIt concept]
- Adipocyte Enhancer-Binding Protein 1 [NCIt concept]
- Ankyrin Repeat Domain-Containing Protein 11 [NCIt concept]
- B-Cell CLL/Lymphoma 9-Like Protein [NCIt concept]
- B-Cell Linker Protein [NCIt concept]
- BCL-6 Corepressor-Like Protein 1 [NCIt concept]
- Biorientation of Chromosomes in Cell Division Protein 1-Like 1 [NCIt concept]
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]
- Cas Scaffolding Protein Family Member 4 [NCIt concept]
- Connector Enhancer of Kinase Suppressor of Ras 1 [NCIt concept]
- Cornifin-A [NCIt concept]
- Crooked Neck-Like Protein 1 [NCIt concept]
- Cyclic Nucleotide-Binding Domain-Containing Protein 1 [NCIt concept]
- Cytochrome B-245 Light Chain [NCIt concept]
- Docking Protein 1 [NCIt concept]
- E3 SUMO-Protein Ligase PIAS3 [NCIt concept]
- E3 Ubiquitin-Protein Ligase Itchy Homolog [NCIt concept]
- Endoplasmic Reticulum Export Factor CTAGE5 [NCIt concept]
- Endoribonuclease ZC3H12A [NCIt concept]
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8 [NCIt concept]
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 1 [NCIt concept]
- Epidermal Growth Factor Receptor Kinase Pathway Substrate 8-Like Protein 3 [NCIt concept]
- Epidermal Growth Factor Receptor Pathway Substrate 15 [NCIt concept]
- Filamin-Binding LIM Protein 1 [NCIt concept]
- GRB2-Associated-Binding Protein 1 [NCIt concept]
- Glucose-Induced Degradation Protein 4 Homolog [NCIt concept]
- Helicase SRCAP [NCIt concept]
- Hematopoietically-Expressed Homeobox Protein HHEX [NCIt concept]
- Histidine-Rich Glycoprotein [NCIt concept]
- Histone-Lysine N-Methyltransferase SETD1A [NCIt concept]
- Histone-Lysine N-Methyltransferase SETD1B [NCIt concept]
- Homeobox Protein Aristaless-Like 3 [NCIt concept]
- Homeobox Protein Aristaless-Like 4 [NCIt concept]
- Lysosomal-Associated Transmembrane Protein 5 [NCIt concept]
- Melanoma Inhibitory Activity Protein 2 [NCIt concept]
- Methyl-CpG-Binding Domain Protein 1 [NCIt concept]
- Methylcytosine Dioxygenase TET2 [NCIt concept]
- Mitochondrial Antiviral-Signaling Protein [NCIt concept]
- Myosin-Binding Protein C, Cardiac-Type [NCIt concept]
- NEDD4-Binding Protein 2 [NCIt concept]
- NUT Family Member 2A [NCIt concept]
- NUT Family Member 2B [NCIt concept]
- NUT Family Member 2D [NCIt concept]
- Non-Receptor Tyrosine-Protein Kinase TNK1 [NCIt concept]
- Nuclear Pore Complex-Interacting Protein Family Member B8 [NCIt concept]
- Oligophrenin-1 [NCIt concept]
- PR Domain Zinc Finger Protein 2 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 1 [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase 2 [NCIt concept]
- Phosphoglycerate Mutase 1 [NCIt concept]
- Phosphoinositide 3-Kinase Adapter Protein 1 [NCIt concept]
- Phospholipid Scramblase 1 [NCIt concept]
- Proline-Rich AKT1 Substrate 1 [NCIt concept]
- Proline-Rich Nuclear Receptor Coactivator 1 [NCIt concept]
- Proline-Rich Protein PRCC [NCIt concept]
- Proline-Rich Transmembrane Protein 2 [NCIt concept]
- Protein ALEX [NCIt concept]
- Protein PRRC1 [NCIt concept]
- Protein-Tyrosine Kinase 2-Beta [NCIt concept]
- Pyruvate Dehydrogenase Protein X Component, Mitochondrial [NCIt concept]
- RING1 and YY1-Binding Protein [NCIt concept]
- Ras Association Domain-Containing Protein 7 [NCIt concept]
- Ras-Related Protein Rab-44 [NCIt concept]
- Ras-Responsive Element-Binding Protein 1 [NCIt concept]
- Refilin-A [NCIt concept]
- Ribonucleoprotein PTB-Binding 1 [NCIt concept]
- Ryanodine Receptor 1 [NCIt concept]
- SH3 Domain-Containing Kinase-Binding Protein 1 [NCIt concept]
- SH3 and Multiple Ankyrin Repeat Domains Protein 2 [NCIt concept]
- SH3 and Multiple Ankyrin Repeat Domains Protein 3 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Shootin-1 [NCIt concept]
- Small Proline-Rich Protein 2A [NCIt concept]
- Suppression of Tumorigenicity 5 Protein [NCIt concept]
- Survival Motor Neuron Protein [NCIt concept]
- T-Cell Surface Protein Tactile [NCIt concept]
- TIR Domain-Containing Adapter Molecule 1 [NCIt concept]
- TNFAIP3-Interacting Protein 1 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Initiation Factor TFIID Subunit 1-Like [NCIt concept]
- Transcriptional Coactivator YAP1 [NCIt concept]
- Trinucleotide Repeat-Containing Gene 6B Protein [NCIt concept]
- Vasodilator-Stimulated Phosphoprotein [NCIt concept]
- WAS/WASL-Interacting Protein Family Member 1 [NCIt concept]
- Zinc Finger Protein 217 [NCIt concept]
- Zinc Finger Protein 341 [NCIt concept]
- Zinc Finger and BTB Domain-Containing Protein 7B [NCIt concept]

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