Transcription Factor 7-Like 1

Preferred Label : Transcription Factor 7-Like 1;

NCIt synonyms : Transcription Factor 7 Like 1; TCF-3; HMG Box Transcription Factor 3; TCF7L1;

NCIt definition : Transcription factor 7-like 1 (588 aa, 63 kDa) is encoded by the human TCF7L1 gene. This protein plays a role in transcriptional regulation that is modulated by the Wnt signaling pathway.;

NCIt note : Transcription factor 7-like 1 is a transcriptional repressor in the absence of catenin beta-1 (CTNNB1) and an activator when bound to CTNNB1.;

Details

Origin ID

C150341;

UMLS CUI

C1570012;

Automatic exact mappings (from CISMeF team)
- Transcription factor 3 [OMIM gene]
- Transcription factor 7-like 1 [OMIM gene]
- transcription factor 3 [ORDO Gene]
- transcription factor 7 like 1 [HGNC gene]
- transcription factor 7-Like 1 protein [MeSH Descriptor]
OMIM relation
- Transcription factor 7-like 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TCF7L1 protein, human [MeSH concept]
- TCF7L1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- TCF7L1 Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- HMG-Box [NCIt concept]
- Nuclear Localization Signal [NCIt concept]
- Proline-Rich Domain [NCIt concept]
gene_product_is_element_in_pathway
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Adherens Junction Assembly Pathway [NCIt concept]
- Arrhythmogenic Right Ventricular Cardiomyopathy Pathway [NCIt concept]
- Basal Cell Carcinoma Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
- Papillary Thyroid Carcinoma Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients