Colorectal Cancer Pathway

Preferred Label : Colorectal Cancer Pathway;

NCIt synonyms : CRC Pathway;

NCIt related terms : Colorectal cancer;

Alternative definition : KEGG: Classically, colorectal cancer (CRC) has been believed to develop from normal mucosa through the premalignant adenoma by the step-wise accumulation of mutations. All CRC display either microsatellite instability (MSI) or chromosome instability (CIN). MSI occurs in 15% of colon cancers and results from inactivation of the DNA mismatch repair (MMR) system by either MMR gene mutations or hypermethylation of the MLH1 promoter. MSI promotes tumorigenesis through generating mutations in target genes that possess coding microsatellite repeats, such as beta-catenin, TGFBR2 and BAX. CIN is found in the majority of colon cancers and leads to a different pattern of gene alterations that contribute to tumor formation. Genes involved in CIN are those coding for APC, K-ras, SMAD4 and p53.;

KEGG ID : hsa05210;

Details

Origin ID

C91466;

UMLS CUI

C2984278;

Automatic exact mappings (from CISMeF team)
- Colorectal cancer [PASCAL descriptor]
- Colorectal cancer [OMIM Phenotype]
- Colorectal cancer [MedDRA Preferred Term]
- Malignant neoplasm of colon and/or rectum (disorder) [SNOMED CT concept]
- colo rectal cancer [Artificial nutrition thesaurus concept]
- colorectal cancer [MedlinePlus Topic]
- colorectal cancer [DO Concept]
- colorectal cancer [Radlex concept]
- colorectal neoplasms [MeSH Descriptor]
Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Adenomatous Polyposis Coli Protein [NCIt concept]
- Adenomatous Polyposis Coli Protein 2 [NCIt concept]
- Apoptosis Regulator BAX [NCIt concept]
- Axin-1 [NCIt concept]
- Bcl2 Antagonist of Cell Death [NCIt concept]
- Caspase-3 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Cytochrome C [NCIt concept]
- DNA Mismatch Repair Protein Mlh1 [NCIt concept]
- DNA Mismatch Repair Protein Msh2 [NCIt concept]
- DNA Mismatch Repair Protein Msh3 [NCIt concept]
- DNA Mismatch Repair Protein Msh6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Netrin Receptor DCC [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 2 [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 3 [NCIt concept]
- Serine/Threonine-Protein Kinase A-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Son of Sevenless Homolog 2 [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Transforming Protein RhoA [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- APC wt Allele [NCIt concept]
- APC2 wt Allele [NCIt concept]
- ARAF wt Allele [NCIt concept]
- AXIN1 wt Allele [NCIt concept]
- AXIN2 wt Allele [NCIt concept]
- BAD wt Allele [NCIt concept]
- BAX wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- CYCS wt Allele [NCIt concept]
- DCC wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MLH1 wt Allele [NCIt concept]
- MSH2 wt Allele [NCIt concept]
- MSH3 wt Allele [NCIt concept]
- MSH6 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAC2 wt Allele [NCIt concept]
- RAC3 wt Allele [NCIt concept]
- RALGDS wt Allele [NCIt concept]
- RHOA wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SOS2 wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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