Melanogenesis Pathway

Preferred Label : Melanogenesis Pathway;

NCIt related terms : Melanogenesis;

Alternative definition : KEGG: Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism.;

KEGG ID : hsa04916;

Details

Origin ID

C91468;

UMLS CUI

C2984280;

See also inter- (CISMeF)
- Melanogenesis [MeSH Descriptor]
Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- 5,6-Dihydroxyindole-2-Carboxylic Acid Oxidase [NCIt concept]
- Adenylate Cyclase Type 5 [NCIt concept]
- Adenylate Cyclase Type 9 [NCIt concept]
- Agouti-Signaling Protein [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha [NCIt concept]
- Calmodulin [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Endothelin Receptor Type B [NCIt concept]
- Endothelin-1 [NCIt concept]
- Frizzled-1 [NCIt concept]
- Frizzled-2 [NCIt concept]
- Frizzled-3 [NCIt concept]
- Frizzled-4 [NCIt concept]
- Frizzled-6 [NCIt concept]
- Frizzled-7 [NCIt concept]
- Frizzled-8 [NCIt concept]
- Frizzled-9 [NCIt concept]
- GTPase HRas [NCIt concept]
- GTPase KRas [NCIt concept]
- GTPase Nras [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(o) Subunit Alpha [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Kit Ligand [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Melanocyte-Stimulating Hormone Receptor [NCIt concept]
- Melanotropin Alpha [NCIt concept]
- Microphthalmia-Associated Transcription Factor [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
- Protein Wnt-10a [NCIt concept]
- Protein Wnt-10b [NCIt concept]
- Protein Wnt-11 [NCIt concept]
- Protein Wnt-16 [NCIt concept]
- Protein Wnt-2 [NCIt concept]
- Protein Wnt-2b [NCIt concept]
- Protein Wnt-4 [NCIt concept]
- Protein Wnt-5a [NCIt concept]
- Protein Wnt-5b [NCIt concept]
- Protein Wnt-6 [NCIt concept]
- Protein Wnt-7a [NCIt concept]
- Protein Wnt-9a [NCIt concept]
- Protein Wnt-9b [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- Proto-Oncogene Wnt-3 [NCIt concept]
- Segment Polarity Protein Dishevelled Homolog DVL-1 [NCIt concept]
- Transcription Factor 7 [NCIt concept]
- Transcription Factor 7-Like 1 [NCIt concept]
- Transcription Factor 7-Like 2 [NCIt concept]
- Tyrosinase [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY5 wt Allele [NCIt concept]
- ADCY9 wt Allele [NCIt concept]
- ASIP wt Allele [NCIt concept]
- CALM1 wt Allele [NCIt concept]
- CAMK2A wt Allele [NCIt concept]
- CREB3L1 wt Allele [NCIt concept]
- CREB3L2 wt Allele [NCIt concept]
- CREB3L3 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- EDN1 wt Allele [NCIt concept]
- EDNRB wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- FZD2 wt Allele [NCIt concept]
- FZD3 wt Allele [NCIt concept]
- FZD4 wt Allele [NCIt concept]
- FZD6 wt Allele [NCIt concept]
- FZD7 wt Allele [NCIt concept]
- FZD8 wt Allele [NCIt concept]
- FZD9 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GNAO1 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- KITLG wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- LEF1 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MC1R wt Allele [NCIt concept]
- MITF wt Allele [NCIt concept]
- NRAS wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- POMC wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PRKCB wt Allele [NCIt concept]
- TCF7 wt Allele [NCIt concept]
- TCF7L1 wt Allele [NCIt concept]
- TCF7L2 wt Allele [NCIt concept]
- TYR wt Allele [NCIt concept]
- TYRP1 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]
- WNT10A wt Allele [NCIt concept]
- WNT10B wt Allele [NCIt concept]
- WNT11 wt Allele [NCIt concept]
- WNT16 wt Allele [NCIt concept]
- WNT2 wt Allele [NCIt concept]
- WNT2B wt Allele [NCIt concept]
- WNT3 wt Allele [NCIt concept]
- WNT4 wt Allele [NCIt concept]
- WNT5A wt Allele [NCIt concept]
- WNT5B wt Allele [NCIt concept]
- WNT6 wt Allele [NCIt concept]
- WNT7A wt Allele [NCIt concept]
- WNT9A wt Allele [NCIt concept]
- WNT9B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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