Melanocyte-Stimulating Hormone Receptor

Preferred Label : Melanocyte-Stimulating Hormone Receptor;

NCIt synonyms : Melanocortin Receptor 1; MC1-R; Melanotropin Receptor; MC1R Protein; MSH-R;

NCIt related terms : MC1R; melanocortin 1 receptor;

NCIt definition : Melanocyte-stimulating hormone receptor (317 aa, 35 kDa) is encoded by the human MC1R gene. This protein plays a role in both hormone binding and melanogenesis.;

Alternative definition : NCI-GLOSS: A protein found in skin and eye cells that make melanin (a pigment that gives color to the skin and helps protect it from damage by ultraviolet light). People with certain changes in the gene for MC1R have a higher risk of developing melanoma (skin cancer that begins in melanocytes).;

NCIt note : Melanocyte-stimulating hormone receptor ligands include melanocyte-stimulating hormones (MSH alpha, beta, and gamma) and adrenocorticotropic hormone (ACTH). This receptor is a regulator of eumelanin and phaeomelanin production.;

Codes from synonyms : CDR0000575845; CDR0000575843; CDR0000561602;

Details

Origin ID

C48827;

UMLS CUI

C4082292;

OMIM relation
- Melanocortin 1 receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MC1R Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Protein Hormone Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Melanogenesis Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Melanogenesis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Actinium Ac 225-DOTA-MTI-201 [NCIt concept]
- Dersimelagon [NCIt concept]
- Gallium Ga 68-VMT02 [NCIt concept]
- Lead Pb 203-VMT01 [NCIt concept]
- Lead Pb 212-VMT01 [NCIt concept]

Keyword's position in hierarchy(ies) :

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