Preferred Label : Lead Pb 212-VMT01;
NCIt synonyms : Lead Pb 212 VMT01; [212Pb]VMT01;
NCIt definition : A radioconjugate composed of the melanocyte-stimulating hormone receptor (MSHR; melanocortin-1
receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting
peptide, VMT01, conjugated to the alpha-emitting radioisotope lead Pb 212, with potential
antineoplastic activity. Upon administration, lead Pb 212-VMT01 targets and binds
to MC1R-expressing tumor cells. This allows for the specific delivery of a cytotoxic
dose of alpha radiation to MC1R-expressing tumor cells. MC1R, a G protein-coupled
receptor expressed by melanocytes that binds to melanocortins, is involved in regulating
mammalian skin and hair color. It is upregulated on the surface of metastatic melanoma
cells.;
NCI Metathesaurus CUI : CL1906845;
Origin ID : C199480;
concept_is_in_subset
- has_target
