Preferred Label : Actinium Ac 225-DOTA-MTI-201;
NCIt synonyms : Actinium-225 Labeled MTI-201; Actinium Ac 225 MTI-201; 225Ac-MTI-201; Actinium Ac 225 MTI 201; Actinium Ac 225 MTI201; 225Ac-DOTA-MTI-201;
NCIt definition : A radioconjugate composed of a melanocyte-stimulating hormone receptor (MSHR; melanocortin-1
receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting
ligand conjugated to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with
potential antineoplastic activity. Upon administration of actinium Ac 225-DOTA-MTI-201,
MT-201 targets and binds to MC1R-expressing melanoma cells, thereby specifically delivering
a cytotoxic dose of alpha radiation to cells expressing MC1R. MC1R, a G protein-coupled
receptor expressed by melanocytes that binds to melanocortins, is involved in regulating
mammalian skin and hair color. It is upregulated on the surface of on uveal and cutaneous
melanoma cells, but not in healthy normal tissues.;
NCI Metathesaurus CUI : CL1799104;
Origin ID : C190693;
UMLS CUI : C5783862;
Semantic type(s)
- concept_is_in_subset
- has_target
