Preferred Label : Dersimelagon;
NCIt synonyms : 1-[2-[(3R,4S)-1-[(3S,4S)-1-Cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl]piperidine-4-carboxylic
Acid; MC1R Agonist MT-7117;
NCIt definition : An orally bioavailable selective, non-peptide melanocortin-1 receptor (MC1R; melanocyte-stimulating
hormone receptor; MSHR; melanin-activating peptide receptor; melanotropin receptor)
agonist, that can potentially be used to prevent phototoxicity. Upon administration,
dersimelagon targets, binds to and activates MC1R. This may prevent phototoxicity
and related pain in erythropoietic protoporphyria (EPP) or X-Linked Protoporphyria
(XLP) patients. MC1R, a G protein-coupled receptor that binds to melanocortins and
are located on melanocytes, is involved in regulating mammalian skin and hair color.;
UNII : 1CWH5SV4G2;
InChIKey : MUNWOYRHJPWQNE-GMFUQMJFSA-N;
CAS number : 1835256-48-8;
Molecule name : MT-7117; MT 7117;
NCI Metathesaurus CUI : CL971489;
Origin ID : C166490;
UMLS CUI : C5239527;
Semantic type(s)
- concept_is_in_subset
- has_target
