Kit Ligand - CISMeF

Preferred Label : Kit Ligand;

NCIt synonyms : Stem Cell Factor; MGF; KITLG; C-Kit Ligand; Mast Cell Growth Factor; Steel Factor; MGF Stem Cell Factor;

NCIt related terms : SCF;

NCIt definition : Kit ligand (273 aa, 31 kDa) is encoded by the human KITLG gene. This protein is involved in melanogenesis, hematopoiesis and mast cell development, migration and function.;

Alternative definition : NCI-GLOSS: A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood cells and increases the number and actions of these cells in the blood. Kit ligand is a type of cytokine and a type of growth factor.;

NCIt note : A soluble form (sKITLG) is produced by proteolytic processing of the extracellular domain of Kit ligand. (UniProt); Kit ligand binds to the receptor-type protein-tyrosine kinase mast/stem cell growth factor receptor Kit. (UniProt);

Codes from synonyms : CDR0000632169; CDR0000045409; CDR0000410736;

Details

Origin ID

C20440;

UMLS CUI

C3887684;

Currated CISMeF NLP mapping
- stem cell factor [MeSH Descriptor]
- stem cell factor [MeSH concept]
OMIM relation
- Kit ligand [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- Hematopoietic Factor Gene [NCIt concept]
- KITLG Gene [NCIt concept]
gene_product_has_associated_anatomy
- Bone Marrow [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- BAD Regulation Pathway [NCIt concept]
- CDK Regulation Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Erythrocyte Differentiation Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- IL17 Signaling Pathway [NCIt concept]
- Mast/Stem Cell Growth Factor Receptor Signaling Pathway [NCIt concept]
- Melanocyte Development Pathway [NCIt concept]
- Melanogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Gametogenesis [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Melanogenesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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