Melanocyte Development Pathway

Preferred Label : Melanocyte Development Pathway;

NCIt related terms : Melanocyte Development and Pigmentation Pathway;

Alternative definition : BIOCARTA: Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development. The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway. The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_melanocytepathway;

Details

Origin ID

C39150;

UMLS CUI

C1513089;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- Apoptosis Regulator Bcl-2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Kit Ligand [NCIt concept]
- Microphthalmia-Associated Transcription Factor [NCIt concept]
pathway_has_gene_element
- BCL2 wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- CREB3 wt Allele [NCIt concept]
- CREB3L4 wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- KITLG wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MITF wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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