Cyclic AMP-Responsive Element-Binding Protein 1

Preferred Label : Cyclic AMP-Responsive Element-Binding Protein 1;

NCIt synonyms : cAMP-Responsive Element Binding Protein 1; CREB-1; cAMP Responsive Element Binding Protein 1; CREB1; Active Transcription Factor CREB; Transactivator Protein; cAMP Responsive Element Binding Protein-1;

NCIt definition : Cyclic AMP-responsive element-binding protein 1 (341 aa, 37 kDa) is encoded by the human CREB1 gene. This protein plays a role in transcriptional regulation.;

NCIt note : cAMP Responsive Element Binding Protein 1 is a homodimeric transcription factor containing 1 KID domain, phosphorylated/stimulated by several protein kinases, that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induces gene transcription in response to hormonal stimulation of the cAMP pathway.;

Details

Origin ID

C38537;

UMLS CUI

C1447703;

OMIM relation
- Camp response element-binding protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CREB1 protein, human [MeSH concept]
- CREB1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CREB Family Gene [NCIt concept]
- CREB1 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine Zipper [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Antigen Processing and Presentation Pathway [NCIt concept]
- CARM1 Transcription Regulation Pathway [NCIt concept]
- CREB Activation Signaling Pathway [NCIt concept]
- Calmodulin Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- FOXA2 and FOXA3 Transcription Factor Signaling Pathway [NCIt concept]
- G-Protein Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- HBx Signaling Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Human Cytomegalovirus Infection Pathway [NCIt concept]
- Huntington's Disease Pathway [NCIt concept]
- Hypoxia-Inducible Factor Pathway [NCIt concept]
- Inhibition of Huntington's Disease Pathway [NCIt concept]
- LKB1 Signaling Pathway [NCIt concept]
- Lysophosphatidic Acid Receptor 4 Signaling Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- Melanocyte Development Pathway [NCIt concept]
- NTRK1/MAPK Signaling Pathway [NCIt concept]
- NTRK1/PI3K/PLC-Gamma Signaling Pathway [NCIt concept]
- Neuronal Survival Pathway [NCIt concept]
- Nongenotropic Androgen Signaling Pathway [NCIt concept]
- Oxidative Stress Pathway [NCIt concept]
- Pain Repression Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- VEGFR3 Lymphatic Signaling Pathway [NCIt concept]
- Vasopressin-Regulated Water Reabsorption Pathway [NCIt concept]
- p38 MAPK Signaling Pathway BioCarta [NCIt concept]
- p38 MAPK/MAPKAP Signaling Pathway [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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