Vasopressin-Regulated Water Reabsorption Pathway

Preferred Label : Vasopressin-Regulated Water Reabsorption Pathway;

NCIt related terms : Vasopressin-regulated water reabsorption;

Alternative definition : KEGG: In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again.;

KEGG ID : hsa04962;

Details

Origin ID

C91485;

UMLS CUI

C2984297;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- Adenylate Cyclase Type 9 [NCIt concept]
- Aquaporin-4 [NCIt concept]
- Arginine-Vasopressin [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 5 [NCIt concept]
- Cytoplasmic Dynein 1 Heavy Chain 1 [NCIt concept]
- Dynactin Subunit 1 [NCIt concept]
- Ras-Related Protein Rab-5A [NCIt concept]
- Ras-Related Protein Rab-5B [NCIt concept]
- Ras-Related Protein Rab-5C [NCIt concept]
- Rho GDP-Dissociation Inhibitor 1 [NCIt concept]
- Vasopressin V2 Receptor [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Beta [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Gamma [NCIt concept]
pathway_has_gene_element
- ADCY9 wt Allele [NCIt concept]
- AQP4 wt Allele [NCIt concept]
- ARHGDIA wt Allele [NCIt concept]
- AVP wt Allele [NCIt concept]
- AVPR2 wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- CREB3 wt Allele [NCIt concept]
- CREB3L1 wt Allele [NCIt concept]
- CREB3L2 wt Allele [NCIt concept]
- CREB3L3 wt Allele [NCIt concept]
- CREB3L4 wt Allele [NCIt concept]
- CREB5 wt Allele [NCIt concept]
- DCTN1 wt Allele [NCIt concept]
- DYNC1H1 wt Allele [NCIt concept]
- PRKACA wt Allele [NCIt concept]
- PRKACB wt Allele [NCIt concept]
- PRKACG wt Allele [NCIt concept]
- RAB5A wt Allele [NCIt concept]
- RAB5B wt Allele [NCIt concept]
- RAB5C wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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