Cyclic AMP-Responsive Element-Binding Protein 3

Preferred Label : Cyclic AMP-Responsive Element-Binding Protein 3;

NCIt synonyms : cAMP Responsive Element Binding Protein 3; Luman; CREB3; CREB-3; Basic Leucine Zipper Protein LZIP; Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1; Transcription Factor LZIP-Alpha; Basic Leucine Zipper Protein; cAMP-Responsive Element Binding Protein 3; cAMP Responsive Element Binding Protein-3;

NCIt definition : Cyclic AMP-responsive element-binding protein 3 (395 aa, 44 kDa) is encoded by the human CREB3 gene. This protein is involved in the modulation of transcription downstream of regulated intramembrane proteolysis.;

NCIt note : Cyclic AMP-responsive element-binding protein 3 is found in the membrane of the endoplasmic reticulum. Stress of this organelle causes cleavage of the protein. This releases the N-terminal cytoplasmic domain which then translocates into the nucleus. (UniProt);

Details

Origin ID

C38539;

UMLS CUI

C1447550;

OMIM relation
- Camp response element-binding protein 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CREB3 protein, human [MeSH Supplementary Concept]
- CREB3 protein, human [MeSH concept]
gene_encodes_gene_product
- CREB Family Gene [NCIt concept]
- CREB3 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine Zipper [NCIt concept]
gene_product_is_element_in_pathway
- Huntington's Disease Pathway [NCIt concept]
- Melanocyte Development Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Vasopressin-Regulated Water Reabsorption Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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