CREB Family Gene

Preferred Label : CREB Family Gene;

NCIt definition : Ubiquitously or widely expressed human CREB Family Genes (bZIP/CREB Family) encode conserved cAMP Responsive Element Binding Proteins, nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI);

Details

Origin ID

C38534;

UMLS CUI

C1511455;

Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_encodes_gene_product
- Cyclic AMP-Dependent Transcription Factor ATF-1 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-2 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-3 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-4 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-5 [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 1 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 3 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 3-Like Protein 4 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 5 [NCIt concept]
- cAMP Responsive Element Binding Protein [NCIt concept]
- cAMP-Responsive Element Modulator [NCIt concept]
- cAMP-Responsive Element-Binding Protein-Like 2 [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_plays_role_in_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
genetic_biomarker_related_to
- FET/CREB Family Fusion Gene [NCIt concept]
- FET/CREB Fusion-Positive [NCIt concept]

Keyword's position in hierarchy(ies) :

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