Cyclic AMP-Dependent Transcription Factor ATF-3

Preferred Label : Cyclic AMP-Dependent Transcription Factor ATF-3;

NCIt synonyms : ATF3; Activating Transcription Factor 3; ATF-3; cAMP-Dependent Transcription Factor ATF-3;

NCIt definition : Cyclic AMP-dependent transcription factor ATF-3 (181 aa, 21 kDa) is encoded by the human ATF3 gene. This protein plays a role in both DNA binding and the repression of gene expression.;

NCIt note : Cyclic AMP-dependent transcription factor ATF-3 binds the cAMP response element (consensus: 5'-GTGACGT[AC][AG]-3'). (UniProt); Alternative isoforms of cyclic AMP-dependent transcription factor ATF-3, which lack the bZIP DNA binding domain, can activate transcription. (UniProt);

Details

Origin ID

C103961;

UMLS CUI

C3542399;

Automatic exact mappings (from CISMeF team)
- Activating transcription factor 3 [OMIM gene]
- activating transcription factor 3 [MeSH Descriptor]
- activating transcription factor 3 [MeSH concept]
- activating transcription factor 3 [HGNC gene]
OMIM relation
- Activating transcription factor 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ATF3 Gene [NCIt concept]
- CREB Family Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine Zipper [NCIt concept]
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- ATF-2 Transcription Factor Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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