NCIt definition : Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB
Family) are conserved nuclear bZIP domain dimeric transcription factors that bind
to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and
cellular promoters and induce gene transcription in response to cAMP signaling pathways.
CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1.
Increased cAMP levels following stimulation activate cAMP-dependent protein kinase
A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive
genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals.
cAMP pathways provide a chief means by which cellular growth, differentiation, and
function can be influenced by extracellular signals. (NCI);