Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha

Preferred Label : Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha;

NCIt synonyms : ATF6-Alpha; Activating Transcription Factor 6 Alpha; Activating Transcription Factor 6; cAMP-Dependent Transcription Factor ATF-6 Alpha; ATF6;

NCIt definition : Cyclic AMP-dependent transcription factor ATF-6 alpha (670 aa, 75 kDa) is encoded by the human ATF6 gene. This protein plays a role in the expression of unfolded protein responsive genes.;

NCIt note : Although it is a transcription factor, cyclic AMP-dependent transcription factor ATF-6 alpha is unusual in that it is synthesized as a endoplasmic reticulum (ER) resident, transmembrane protein. During ER stress the protein is cleaved and the N-terminal cytoplasmic domain translocates into the nucleus.; Cyclic AMP-dependent transcription factor ATF-6 alpha binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). (UniProt);

Details

Origin ID

C113618;

UMLS CUI

C0665313;

Automatic exact mappings (from CISMeF team)
- Activating transcription factor 6 [OMIM gene]
- activating transcription factor 6 [MeSH concept]
- activating transcription factor 6 [MeSH Descriptor]
- activating transcription factor 6 [ORDO Gene]
- activating transcription factor 6 [HGNC gene]
OMIM relation
- Activating transcription factor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ATF6 protein, human [MeSH Supplementary Concept]
- ATF6 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ATF6 Gene [NCIt concept]
- CREB Family Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Sequence-Specific DNA Binding Protein [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine Zipper [NCIt concept]
- bZIP Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- p38-alpha and p38-beta Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Stress Response Signaling [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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