activating transcription factor 6

Preferred Label : activating transcription factor 6;

MeSH definition : One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.;

MeSH synonym : atf6 transcription factor; transcription factor, atf6;

Wikipedia link : https://en.wikipedia.org/wiki/Activating transcription factor 6;

Is substance : O;

Details

Origin ID

D051702;

UMLS CUI

C1571641;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Activating transcription factor 6 [OMIM gene]
- Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha [NCIt concept]
- activating transcription factor 6 [ORDO Gene]
- activating transcription factor 6 [HGNC gene]
Record concept(s)
- activating transcription factor 6 [MeSH concept]
Related MeSH Supplementary Concept(s)
- ATF6 protein, human [MeSH Supplementary Concept]
- ATF6B protein, human [MeSH Supplementary Concept]
- Atf6 protein, mouse [MeSH Supplementary Concept]
- Atf6 protein, rat [MeSH Supplementary Concept]
- Atf6b protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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