MAPKinase Signaling Pathway

Preferred Label : MAPKinase Signaling Pathway;

Alternative definition : BIOCARTA: The ever evolving mitogen-activated protein kinase (MAP kinase) pathways consist of four major groupings and numerous related proteins which constitute interrelated signal transduction cascades activated by stimuli such as growth factors, stress, cytokines and inflammation. The four major groupings are the Erk, JNK or SAPK, p38, and the Big MAPK or ERK5 cascades. Signals from cell surface receptors such as GPCRs and growth factor receptors are transduced, directly or via small G proteins such as ras and rac, to multiple tiers of protein kinases that amplify these signals and/or regulate each other. In some cascades the first activation tier involves the MAPKKKKs, MAP kinase kinase kinase kinases or MAP4K proteins. The next tier are the serine/threonine MAPKKKs, MAP kinase kinase kinase or MAP3Ks such as RAF, TAK, ASK, and MEKK1. This level has the greatest amount of cross-communication currently known. The serine/threonine/tyrosine MAPKKs, MAP Kinase kinases or MAP2Ks, such as the MKK and MEK kinases, are one step up from the MAP kinase cascade, phosphorylating and activating these kinases. The focal tier, the MAPKs or MAP kinases includes JNK1, p38, and ERKs, and are the kinases that give each cascade its name. The endpoints of these cascades include the MAPK activated protein kinases (MAPKAPK) and some of the numerous transcription factors that regulate genes involved in apoptosis, inflammation, cell growth and differentiation. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_mapkPathway;

Details

Origin ID

C39146;

UMLS CUI

C1518103;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- CCAAT/Enhancer Binding Protein Alpha [NCIt concept]
- Cyclic AMP-Dependent Transcription Factor ATF-2 [NCIt concept]
- Cyclic AMP-Responsive Element-Binding Protein 1 [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 6 [NCIt concept]
- ETS Domain-Containing Protein Elk-1 [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- GTPase HRas [NCIt concept]
- Growth Factor Receptor-Bound Protein 2 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- MAP Kinase-Interacting Serine/Threonine-Protein Kinase 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 4 [NCIt concept]
- Mitogen-Activated Protein Kinase 6 [NCIt concept]
- Mitogen-Activated Protein Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 4 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Protein Max [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAF Proto-Oncogene Serine/Threonine-Protein Kinase [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Receptor-Interacting Serine/Threonine-Protein Kinase 1 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-2 [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-5 [NCIt concept]
- Ribosomal Protein S6 Kinase Beta-2 [NCIt concept]
- SHC-Transforming Protein 1 [NCIt concept]
- Serine/Threonine-Protein Kinase B-Raf [NCIt concept]
- Serine/Threonine-Protein Kinase PAK 1 [NCIt concept]
- Signal Transducer and Activator of Transcription 1-Alpha/Beta [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TNF Receptor-Associated Factor 2 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor Sp1 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Tumor Necrosis Factor Receptor 1-Associated DEATH Domain Protein [NCIt concept]
pathway_has_gene_element
- ATF2 wt Allele [NCIt concept]
- BRAF wt Allele [NCIt concept]
- CEBPA wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CREB1 wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- EGFR wt Allele [NCIt concept]
- ELK1 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GRB2 wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP2K3 wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAP2K6 wt Allele [NCIt concept]
- MAP3K1 wt Allele [NCIt concept]
- MAP3K13 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP3K4 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAP3K8 wt Allele [NCIt concept]
- MAP4K1 wt Allele [NCIt concept]
- MAP4K4 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK4 wt Allele [NCIt concept]
- MAPK6 wt Allele [NCIt concept]
- MAPK7 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- MAX wt Allele [NCIt concept]
- MKNK1 wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PAK1 wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RAF1 wt Allele [NCIt concept]
- RIPK1 wt Allele [NCIt concept]
- RPS6KA2 wt Allele [NCIt concept]
- RPS6KA5 wt Allele [NCIt concept]
- RPS6KB2 wt Allele [NCIt concept]
- SHC1 wt Allele [NCIt concept]
- SP1 wt Allele [NCIt concept]
- STAT1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TRADD wt Allele [NCIt concept]
- TRAF2 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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