Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4

Preferred Label : Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4;

NCIt synonyms : MAP4K4; MAPK/ERK Kinase Kinase Kinase 4; MEK Kinase Kinase 4; HPK/GCK-Like Kinase HGK; NCK Interacting Kinase; HPK/GCK-Like Kinase; Hematopoietic Progenitor Kinase/Germinal Center Kinase-Like Kinase; MEKKK4; EC 2.7.11.1; HGK Protein; Nck-Interacting Kinase;

NCIt definition : Mitogen-activated protein kinase kinase kinase kinase 4 (1239 aa, 142 kDa) is encoded by the human MAP4K4 gene. This protein is involved in serine/threonine phosphorylation and modulation of JNK signal pathways.;

Details

Origin ID

C26490;

UMLS CUI

C1431671;

OMIM relation
- Mitogen-activated protein kinase kinase kinase kinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MAP4K4 protein, human [MeSH Supplementary Concept]
- MAP4K4 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- MAP4K4 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- CD40L Signaling Pathway [NCIt concept]
- Ceramide Signaling Pathway BioCarta [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- Ephrin B Forward Signaling Pathway [NCIt concept]
- IL1R Signaling Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPKinase Signaling Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- TNF Stress Related Signaling Pathway [NCIt concept]
- dsRNA Induction Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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