dsRNA Induction Pathway

Preferred Label : dsRNA Induction Pathway;

NCIt related terms : Double Stranded RNA Induced Gene Expression;

Alternative definition : BIOCARTA: One defense against viral infection is provided by PKR, double-stranded RNA activated protein kinase. When PKR interacts with dsRNA found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to inactivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_rnaPathway;

Details

Origin ID

C39224;

UMLS CUI

C1515618;

Semantic type(s)
- Genetic Function [UMLS semantic type]
has_gene_product_element
- Cellular Tumor Antigen p53 [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Delta [NCIt concept]
pathway_has_gene_element
- CHUK wt Allele [NCIt concept]
- EIF2AK2 wt Allele [NCIt concept]
- EIF2B4 wt Allele [NCIt concept]
- MAP3K14 wt Allele [NCIt concept]
- MAP4K4 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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