Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase

Preferred Label : Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase;

NCIt synonyms : p68 Kinase; PRKR; Interferon-Inducible Double Stranded RNA Dependent Protein Kinase; Interferon-Inducible RNA-Dependent Protein Kinase; Interferon-Induced Double-Stranded RNA-Activated Protein Kinase; P1/eIF2A Protein Kinase; PKR; EC 2.7.11.1; Interferon-Inducible elF2Alpha Kinase; eIF-2A protein kinase 2; Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2; Protein Kinase RNA-Activated; EIF2AK2;

NCIt definition : Interferon-induced, double-stranded RNA-activated protein kinase (551 aa, 62 kDa) is encoded by the human EIF2AK2 gene. This protein is involved in both serine/threonine phosphorylation and the inhibition of protein synthesis.;

NCIt note : Protein_Plays_Role_In_Biological_Process: Inhibition of Protein Synthesis;

Details

Origin ID

C34095;

UMLS CUI

C3710914;

OMIM relation
- Eukaryotic translation initiation factor 2-alpha kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- EIF2AK2 protein, human [MeSH concept]
- EIF2AK2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EIF2AK2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Translation Process Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Double-Stranded RNA Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Beta-Catenin Accumulation Pathway [NCIt concept]
- Bone Remodeling Pathway [NCIt concept]
- Ceramide Signaling Pathway PID [NCIt concept]
- PDGFR-beta Signaling Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- dsRNA Induction Pathway [NCIt concept]
- eIF2 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Translational Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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