eIF2 Regulation Pathway

Preferred Label : eIF2 Regulation Pathway;

NCIt related terms : Regulation of eIF2;

Alternative definition : BIOCARTA: Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_eif2Pathway;

Details

Origin ID

C39061;

UMLS CUI

C1515619;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Aminoacyl tRNA Synthase Complex-Interacting Multifunctional Protein 2 [NCIt concept]
- Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1 [NCIt concept]
- Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3 [NCIt concept]
- Eukaryotic Translation Initiation Factor 5 [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Delta [NCIt concept]
- Translation Initiation Factor EIF-2B Subunit Epsilon [NCIt concept]
pathway_has_gene_element
- AIMP2 wt Allele [NCIt concept]
- EIF2AK1 wt Allele [NCIt concept]
- EIF2AK2 wt Allele [NCIt concept]
- EIF2AK3 wt Allele [NCIt concept]
- EIF2B4 wt Allele [NCIt concept]
- EIF2B5 wt Allele [NCIt concept]
- EIF5 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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