Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1

Preferred Label : Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1;

NCIt synonyms : Heme-Regulated Inhibitor; Hemin-Sensitive Initiation Factor 2-Alpha Kinase; Heme-Regulated Initiation Factor 2 Alpha Kinase; Heme-Controlled Repressor; HCR; Heme-Regulated Initiation Factor 2-Alpha Kinase; EC 2.7.11.1; Heme-Regulated Eukaryotic Initiation Factor eIF-2-Alpha Kinase; EIF2AK1;

NCIt definition : Eukaryotic translation initiation factor 2-alpha kinase 1 (630 aa, 71 kDa) is encoded by the human EIF2AK1 gene. This protein plays a role in both the inhibition of protein synthesis and serine/threonine phosphorylation.;

NCIt note : The enzymatic activity of eukaryotic translation initiation factor 2-alpha kinase 1 protein is regulated by heme levels. The presence of heme inhibits the activity of this protein whereas low heme levels cause induction of activity.;

Details

Origin ID

C97451;

UMLS CUI

C4308350;

OMIM relation
- Eukaryotic translation initiation factor 2-alpha kinase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- EIF2AK1 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- EIF2AK1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Translation Process Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- eIF2 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- Translational Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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