EIF2AK1 wt Allele

Preferred Label : EIF2AK1 wt Allele;

NCIt synonyms : HCR; PRO1362; Eukaryotic Translation Initiation Factor 2-Alpha Kinase 1 wt Allele; KIAA1369; HRI;

NCIt definition : Human EIF2AK1 wild-type allele is located within 7p22 and is approximately 35 kb in length. This allele, which encodes eukaryotic translation initiation factor 2-alpha kinase 1 protein, is involved in the inhibition of translation initiation in response to various stress stimuli.;

NCIt note : The enzymatic activity of eukaryotic translation initiation factor 2-alpha kinase 1 protein is regulated by heme levels. The presence of heme inhibits the activity of this protein whereas low heme levels cause induction of activity.;

GenBank Accession Number : BC006524;

Details

Origin ID

C97324;

UMLS CUI

C4759862;

OMIM relation
- Eukaryotic translation initiation factor 2-alpha kinase 1 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 7p22 [NCIt concept]
gene_is_element_in_pathway
- eIF2 Regulation Pathway [NCIt concept]
gene_plays_role_in_process
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Stress Response Signaling [NCIt concept]
- Translational Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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