Amphiregulin - CISMeF

Preferred Label : Amphiregulin;

NCIt synonyms : Colorectum Cell-Derived Growth Factor; CRDGF; Keratinocyte-Derived Autocrine Factor; Schwannoma-Derived Growth Factor; AR; SDGF; AMR; AREG;

NCIt definition : Amphiregulin (252 aa, 28 kDa) is encoded by the human AREG and AREGB genes. This protein is involved in autocrine and mitogen signaling pathways.;

NCIt note : The active form of amphiregulin is produced by proteolytic cleavages that remove 100 N-terminal amino acids and 65 C-terminal amino acids from the full length precursor protein. (UniProt);

Details

Origin ID

C20431;

UMLS CUI

C3884535;

Automatic exact mappings (from CISMeF team)
- Adrenomedullin receptor [OMIM gene]
- Aldo-keto reductase family 1, member b1 [OMIM gene]
- Amphiregulin [MeSH Descriptor]
- Amphiregulin [MeSH concept]
- Amphiregulin [OMIM gene]
- Androgen receptor [OMIM gene]
- Aortic valve insufficiency [ICD-11 Category]
- Arising in (attribute) [SNOMED CT concept]
- amphiregulin [HGNC gene]
- androgen receptor [ORDO Gene]
- attractive–mixed–repulsive classification [IUPAC Term]
- drug evaluation [MeSH Descriptor]
- magnetic resonance imaging [MeSH Descriptor]
- secreted LY6/PLAUR domain containing 1 [ORDO Gene]
OMIM relation
- Amphiregulin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AREG protein, human [MeSH Supplementary Concept]
- AREG protein, human [MeSH concept]
gene_encodes_gene_product
- AREG Gene [NCIt concept]
- Growth Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- ERBB Family Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Regulation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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