Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3

Preferred Label : Eukaryotic Translation Initiation Factor 2-Alpha Kinase 3;

NCIt synonyms : HsPEK; Pancreatic eIF2-Alpha Kinase; EC 2.7.11.1; PRKR-Like Endoplasmic Reticulum Kinase; Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3; PKR-Like ER Kinase; PERK; EIF2AK3;

NCIt definition : Eukaryotic translation initiation factor 2-alpha kinase 3 (1116 aa, 125 kDa) is encoded by the human EIF2AK3 gene. This protein plays a role in the inhibition of protein synthesis.;

Details

Origin ID

C102829;

UMLS CUI

C1137836;

OMIM relation
- Eukaryotic translation initiation factor 2-alpha kinase 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- EIF2AK3 protein, human [MeSH concept]
- EIF2AK3 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- EIF2AK3 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- eIF2 Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Translational Repression [NCIt concept]
is_target
- PERK Inhibitor HC-5404-FU [NCIt concept]
- PERK Inhibitor NMS-03597812 [NCIt concept]

Keyword's position in hierarchy(ies) :

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