Preferred Label : PERK Inhibitor NMS-03597812;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine kinase protein kinase R (PKR)-like
endoplasmic reticulum kinase (PERK; eukaryotic translation initiation factor 2-alpha
kinase 3; EIF2AK3; PEK), with potential antineoplastic activity. Upon oral administration,
PERK inhibitor NMS-03597812 inhibits the activity of PERK. This prevents the activation
of the PERK pathway and inhibits unfolded protein response (UPR) stress adaptation,
which may lead to tumor cell apoptosis and the inhibition of tumor growth. PERK, one
of the key sensors for the UPR, plays a key role in the response to and resolution
of endoplasmic reticulum (ER) stress and also in tumor angiogenesis and survival.;
Molecule name : NMS-03597812; NMS 03597812;
NCI Metathesaurus CUI : CL1772562;
Origin ID : C184373;
UMLS CUI : C5666921;
Semantic type(s)
- concept_is_in_subset
- has_target
