Beta-Catenin Accumulation Pathway

Preferred Label : Beta-Catenin Accumulation Pathway;

NCIt related terms : Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages;

Alternative definition : BIOCARTA: Lipopolysaccharide (LPS) from XX bacteria induces a wide range of inflammatory responses, including the response of alveolar macrophages to bacteria in the lungs. CD14 and the Toll-like receptor TLR4 are activated by LPS, initiating a signaling cascade that activates PI3 kinase and increases synthesis of the inositol phosphate PIP3. PIP3 activates the inositol phosphate dependent protein kinase PDK1, which activates AKT (protein kinase B). One of the key actions of AKT is to block apoptosis. AKT phosphorylation of NF-kB promotes the survival and activation of macrophages responding to LPS. Another substrate of AKT is the protein kinase Gsk3-beta. AKT phosphorylates and deactivates Gsk3-beta. Non-phosphorylated Gsk3-beta is active and phosphorylates beta-catenin, leading to its degradation in the ubiquitin dependent proteasome pathway. Stimulation by LPS causes the accumulation of beta-catenin in the nucleus and the activation of genes in concert with the transcription factor LEF1. This pathway is probably not restricted to alveolar pathway, but leads to the activation of beta-catenin dependent genes by LPS in other cells as well. Other pathways regulate this pathway also, such as the modulation of PI3 kinase activity by ceramide and the inhibition of Gsk3-beta activity by the Wnt/frizzled/disheveled (DSH) pathway. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_gsk3Pathway;

Details

Origin ID

C39098;

UMLS CUI

C1511110;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- Adenomatous Polyposis Coli Protein [NCIt concept]
- Axin-1 [NCIt concept]
- Catenin Beta-1 [NCIt concept]
- Dickkopf-Related Protein 1 [NCIt concept]
- F-Box/WD Repeat-Containing Protein 1A [NCIt concept]
- Frizzled-1 [NCIt concept]
- G1/S-Specific Cyclin-D1 [NCIt concept]
- Gap Junction Alpha-1 Protein [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 1 [NCIt concept]
- Lipopolysaccharide-Binding Protein [NCIt concept]
- Low-Density Lipoprotein Receptor-Related Protein 6 [NCIt concept]
- Lymphoid Enhancer-Binding Factor 1 [NCIt concept]
- Monocyte Differentiation Antigen CD14 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Proto-Oncogene Wnt-1 [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- Segment Polarity Protein Dishevelled Homolog DVL-1 [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]
- Toll-Interacting Protein [NCIt concept]
- Toll-Like Receptor 4 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Wnt Inhibitory Factor 1 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- APC wt Allele [NCIt concept]
- AXIN1 wt Allele [NCIt concept]
- BTRC wt Allele [NCIt concept]
- CCND1 wt Allele [NCIt concept]
- CD14 wt Allele [NCIt concept]
- CTNNB1 wt Allele [NCIt concept]
- DKK1 wt Allele [NCIt concept]
- DVL1 wt Allele [NCIt concept]
- EIF2AK2 wt Allele [NCIt concept]
- FZD1 wt Allele [NCIt concept]
- GJA1 wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GSK3B wt Allele [NCIt concept]
- IRAK1 wt Allele [NCIt concept]
- LBP wt Allele [NCIt concept]
- LRP6 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PPP2R3B wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- TOLLIP wt Allele [NCIt concept]
- WIF1 wt Allele [NCIt concept]
- WNT1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients