Preferred Label : Catenin Beta-1;
NCIt synonyms : Beta-Catenin; PRO2286; CTNNB1; Cadherin-Associated Protein, Beta 1 (88kD); Cadherin-Associated Protein, Beta; Catenin, Beta-1; Beta Catenin;
NCIt definition : Catenin beta-1 (781 aa, 85 kDa) is encoded by the human CTNNB1 gene. This protein
is involved in Wnt signaling, adherens junction structure, and the regulation of cell
growth.;
NCIt note : Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called
the zonula adherens) are critical for the establishment and maintenance of epithelial
layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate
a signal that neighboring cells are present, and anchor the actin cytoskeleton. In
serving these roles, AJs regulate normal cell growth and behavior. At several stages
of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia.
This process, which involves the disruption and reestablishment of epithelial cell-cell
contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function
in the transmission of the contact inhibition' signal, which instructs cells to stop
dividing once an epithelial sheet is complete. (from OMIM);
Origin ID : C17478;
UMLS CUI : C1531189;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_gene_product_variant
- gene_product_has_organism_source
- gene_product_is_element_in_pathway
- gene_product_malfunction_associated_with_disease
- gene_product_plays_role_in_biological_process
- is_target
