" /> APC wt Allele - CISMeF





Preferred Label : APC wt Allele;

NCIt synonyms : FPC; DP2; DP2.5; GS; Protein Phosphatase 1, Regulatory Subunit 46 Gene; DP3; FAP; PPP1R46; Adenomatosis Polyposis Coli Gene; APC Regulator of WNT Signaling Pathway wt Allele; BTPS2; APC, WNT Signaling Pathway Regulator Gene;

NCIt definition : Human APC wild-type allele is located within 5q21-q22 and is approximately 108 kb in length. This allele, which encodes adenomatosis polyposis coli protein, is involved in the progression of Wnt protein mediated signaling. Mutations in this gene are associated with familial adenomatous polyposis, an autosomal dominant pre-malignant disease that usually progresses to malignancy.;

NCIt note : Mutation of the APC gene can also lead to Gardner's syndrome, hereditary desmoid disease/familial infiltrative fibromatosis, medulloblastoma, Turcot syndrome, and sporadic colorectal cancer.;

GenBank Accession Number : NM_000038;

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30/05/2025


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