NCIt definition : Human APC wild-type allele is located within 5q21-q22 and is approximately 108 kb
in length. This allele, which encodes adenomatosis polyposis coli protein, is involved
in the progression of Wnt protein mediated signaling. Mutations in this gene are associated
with familial adenomatous polyposis, an autosomal dominant pre-malignant disease that
usually progresses to malignancy.;
NCIt note : Mutation of the APC gene can also lead to Gardner's syndrome, hereditary desmoid disease/familial
infiltrative fibromatosis, medulloblastoma, Turcot syndrome, and sporadic colorectal
cancer.;