TGF Beta Signaling Pathway BioCarta

Preferred Label : TGF Beta Signaling Pathway BioCarta;

NCIt related terms : TGF beta signaling pathway;

Alternative definition : BIOCARTA: TGF-beta regulates growth and proliferation of cells, blocking growth of many cell types. The TGF-beta receptor includes type 1 and type 2 subunits that are serine-threonine kinases and that signal through the SMAD family of transcriptional regulators. Defects in TGF-beta signaling, including mutation in SMADs, have been associated with cancer in humans. Prior to activation, receptor regulated SMADs are anchored to the cell membrane by factors like SARA (SMAD Anchor for Receptor Activation) that brings the SMADs into proximity of the TGF receptor kinases. Binding of TGF induces phosphorylation and activation of the TGF-beta R1 receptor by the TGF-beta R2 receptor. The activated TGF-beta R1 phosphorylates SMAD2 and SMAD3, which bind to the SMAD4 mediator to move into the nucleus and form complexes that regulate transcription. SMADs regulate transcription in several ways, including binding to DNA, interacting with other transcription factors, and interacting with transcription corepressors and coactivators like p300 and CBP. SMAD-7 represses signaling by other SMADs to down-regulate the system. Other signaling pathways, like the MAP kinase-ERK cascade activated by TGF-beta signaling, modulate SMAD activation. SnoN also regulates TGF-beta signaling, by binding to SMADs to block transcriptional activation. TGF-beta signaling causes degradation of SnoN, releasing SMADs to regulate transcription, and also activates expression of SnoN, to down-regulate SMAD signaling at later times. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tgfbPathway;

Details

Origin ID

C39251;

UMLS CUI

C1515163;

Semantic type(s)
- Conceptual Entity [UMLS semantic type]
has_gene_product_element
- Adenomatous Polyposis Coli Protein [NCIt concept]
- CCN Family Member 2 [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Cadherin-1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 2 [NCIt concept]
- Histone Acetyltransferase p300 [NCIt concept]
- Latent-Transforming Growth Factor Beta-Binding Protein 2 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase Kinase Kinase 7 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 5 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 7 [NCIt concept]
- Nuclear Receptor Subfamily 2 Group C Member 2 [NCIt concept]
- SKI-Like Protein [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- TGF-Beta-Activated Kinase 1 and MAP3K7-Binding Protein 1 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Vitamin K-Dependent Protein C [NCIt concept]
- Zinc Finger FYVE Domain-Containing Protein 9 [NCIt concept]
pathway_has_gene_element
- ACVR1B wt Allele [NCIt concept]
- ACVR2A wt Allele [NCIt concept]
- ACVR2B wt Allele [NCIt concept]
- APC wt Allele [NCIt concept]
- CCN2 wt Allele [NCIt concept]
- CDH1 wt Allele [NCIt concept]
- CDKN2B wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- EP300 wt Allele [NCIt concept]
- MAP2K1 wt Allele [NCIt concept]
- MAP2K2 wt Allele [NCIt concept]
- MAP3K7 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- NR2C2 wt Allele [NCIt concept]
- PROC wt Allele [NCIt concept]
- SKIL wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- SMAD7 wt Allele [NCIt concept]
- TAB1 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- ZFYVE9 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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