SKI-Like Protein

Preferred Label : SKI-Like Protein;

NCIt synonyms : SNOA; SKI-Related Protein; SNON; SKIL; SKI-Like Protein-SKIL; SKI-Like; SNO; SKI-Like Protein SKIL; SKI-Related Oncogene SNO Protein; SKI-Related Oncogene;

NCIt definition : Ski-like protein (684 aa, 77 kDa) is encoded by the human SKIL gene. This protein plays a role in the regulation of both gene transcription and signal transduction.;

NCIt note : Ski-like protein is expressed as alternative isoforms: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling.;

Details

Origin ID

C29970;

UMLS CUI

C1448598;

OMIM relation
- Ski-like [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SKIL protein, human [MeSH concept]
- SKIL protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Regulatory Gene [NCIt concept]
- SKIL Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_is_element_in_pathway
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation Regulatory Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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