Mothers Against Decapentaplegic Homolog 3

Preferred Label : Mothers Against Decapentaplegic Homolog 3;

NCIt synonyms : Mothers Against Decapentaplegic Homolog 3 Protein; MAD Homolog 3; Mothers Against Decapentaplegic, Drosophila, Homolog of, 3; MADH3; SMAD3 Protein; SMA- and MAD-Related Protein 3; SMAD Family Member 3; hSMAD3; Smad3; Mad Protein Homolog 3; JV15-2; hMAD-3; Mad3; Mothers Against DPP Homolog 3; Mad Homolog JV15-2; SMAD 3; Mothers Against Decapentaplegic Homolog-3 Protein;

NCIt definition : Mothers against decapentaplegic homolog 3 (425 aa, 48 kDa) is encoded by the human SMAD3 gene. This protein plays a role in the modulation of transforming growth factor (TGF)-beta-mediated signaling and gene expression.;

NCIt note : Mothers against decapentaplegic homolog 3 binds to the transforming growth factor (TGF)-beta response element (TRE) in the promoter region of TGF-beta responsive genes. (UniProt);

Details

Origin ID

C18034;

UMLS CUI

C0529119;

Currated CISMeF NLP mapping
- Smad3 protein [MeSH concept]
- smad3 protein [MeSH Descriptor]
OMIM relation
- Smad family member 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SMAD3 protein, human [MeSH Supplementary Concept]
- SMAD3 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- SMAD3 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transcription Factor Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Binding Protein [NCIt concept]
- Transcription Coactivator [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- NFKB Activation Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Regulation of Cytoplasmic and Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- Regulation of Nuclear SMAD2/3 Signaling Pathway [NCIt concept]
- T-Cell Activation Pathway [NCIt concept]
- TGF Beta Signaling Pathway BioCarta [NCIt concept]
- TGF-Beta Receptor Signaling Pathway [NCIt concept]
- TGF-beta Signaling Pathway KEGG [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Colorectal Adenocarcinoma [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Binding [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transcriptional Activation [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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