Chagas Disease Pathway

Preferred Label : Chagas Disease Pathway;

NCIt synonyms : T. cruzi Infection Pathway; Trypanosoma cruzi Infection Pathway;

NCIt related terms : Chagas disease (American trypanosomiasis); Chagas disease;

Alternative definition : KEGG: Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2 signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.;

KEGG ID : hsa05142;

Details

Origin ID

C91525;

UMLS CUI

C2984330;

Automatic exact mappings (from CISMeF team)
- American trypanosomiasis [ORDO Disease]
- Chagas Disease [DeCS]
- Chagas disease [DO Concept]
- Chagas disease [PASCAL descriptor]
- Chagas disease [Blood Transfusion thesaurus concept]
- Chagas' disease [MedDRA LLT]
- Chagas' disease [ICD-10 category]
- Infection caused by Trypanosoma cruzi (disorder) [SNOMED CT concept]
- chagas disease [MedlinePlus Topic]
- chagas disease [MeSH concept]
- chagas disease [MeSH Descriptor]
See also inter- (CISMeF)
- Chagas disease [ICD-11 Category]
Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-3 [NCIt concept]
- 1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Beta-4 [NCIt concept]
- Angiotensin-Converting Enzyme [NCIt concept]
- B2 Bradykinin Receptor [NCIt concept]
- C-C Motif Chemokine 2 [NCIt concept]
- C-C Motif Chemokine 3 [NCIt concept]
- C-C Motif Chemokine 3-Like 1 [NCIt concept]
- C-C Motif Chemokine 5 [NCIt concept]
- CASP8 and FADD-Like Apoptosis Regulator [NCIt concept]
- Calreticulin [NCIt concept]
- Caspase-8 [NCIt concept]
- Complement C1q Subcomponent Subunit A [NCIt concept]
- Complement C1q Subcomponent Subunit B [NCIt concept]
- Complement C1q Subcomponent Subunit C [NCIt concept]
- Dual Specificity Mitogen-Activated Protein Kinase Kinase 4 [NCIt concept]
- FAS-Associated Death Domain Protein [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-1 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(i) Subunit Alpha-2 [NCIt concept]
- Guanine Nucleotide-Binding Protein G(k) Subunit Alpha [NCIt concept]
- Guanine Nucleotide-Binding Protein G(o) Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Interferon Beta [NCIt concept]
- Interferon Gamma [NCIt concept]
- Interferon Gamma Receptor 1 [NCIt concept]
- Interferon Gamma Receptor 2 [NCIt concept]
- Interleukin-1 Beta [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 1 [NCIt concept]
- Interleukin-1 Receptor-Associated Kinase 4 [NCIt concept]
- Interleukin-10 [NCIt concept]
- Interleukin-12 Subunit Alpha [NCIt concept]
- Interleukin-12 Subunit Beta [NCIt concept]
- Interleukin-2 [NCIt concept]
- Interleukin-6 [NCIt concept]
- Interleukin-8 [NCIt concept]
- Mitogen-Activated Protein Kinase 1 [NCIt concept]
- Mitogen-Activated Protein Kinase 10 [NCIt concept]
- Mitogen-Activated Protein Kinase 11 [NCIt concept]
- Mitogen-Activated Protein Kinase 12 [NCIt concept]
- Mitogen-Activated Protein Kinase 13 [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Mitogen-Activated Protein Kinase 3 [NCIt concept]
- Mitogen-Activated Protein Kinase 8 [NCIt concept]
- Mitogen-Activated Protein Kinase 9 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 3 [NCIt concept]
- NF-Kappa-B Inhibitor Alpha [NCIt concept]
- Nitric Oxide Synthase, Inducible [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Beta [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Phosphoinositide 3-Kinase Regulatory Subunit 5 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- RAC-Beta Serine/Threonine Kinase [NCIt concept]
- RAC-Gamma Serine/Threonine Kinase [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha Isoform [NCIt concept]
- Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Alpha Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 55 kDa Regulatory Subunit B Beta Isoform [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Delta Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Epsilon Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Gamma Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD3 Zeta Chain [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- TIR Domain-Containing Adapter Molecule 1 [NCIt concept]
- TNF Receptor-Associated Factor 6 [NCIt concept]
- Toll-Like Receptor 2 [NCIt concept]
- Toll-Like Receptor 4 [NCIt concept]
- Toll-Like Receptor 6 [NCIt concept]
- Toll-Like Receptor 9 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Transcription Factor p65 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Transforming Growth Factor Beta-2 [NCIt concept]
- Transforming Growth Factor Beta-3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT2 wt Allele [NCIt concept]
- AKT3 wt Allele [NCIt concept]
- BDKRB2 wt Allele [NCIt concept]
- C1QA wt Allele [NCIt concept]
- C1QB wt Allele [NCIt concept]
- C1QC wt Allele [NCIt concept]
- CALR wt Allele [NCIt concept]
- CASP8 wt Allele [NCIt concept]
- CCL2 wt Allele [NCIt concept]
- CCL3 wt Allele [NCIt concept]
- CCL3L1 wt Allele [NCIt concept]
- CCL5 wt Allele [NCIt concept]
- CD247 wt Allele [NCIt concept]
- CD3D wt Allele [NCIt concept]
- CD3E wt Allele [NCIt concept]
- CD3G wt Allele [NCIt concept]
- CFLAR wt Allele [NCIt concept]
- CHUK wt Allele [NCIt concept]
- CXCL8 wt Allele [NCIt concept]
- FADD wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- GNAI1 wt Allele [NCIt concept]
- GNAI2 wt Allele [NCIt concept]
- GNAI3 wt Allele [NCIt concept]
- GNAO1 wt Allele [NCIt concept]
- IFNB1 wt Allele [NCIt concept]
- IFNG wt Allele [NCIt concept]
- IFNGR1 wt Allele [NCIt concept]
- IFNGR2 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IL10 wt Allele [NCIt concept]
- IL12A wt Allele [NCIt concept]
- IL12B wt Allele [NCIt concept]
- IL1B wt Allele [NCIt concept]
- IL2 wt Allele [NCIt concept]
- IL6 wt Allele [NCIt concept]
- IRAK1 wt Allele [NCIt concept]
- IRAK4 wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAP2K4 wt Allele [NCIt concept]
- MAPK1 wt Allele [NCIt concept]
- MAPK10 wt Allele [NCIt concept]
- MAPK11 wt Allele [NCIt concept]
- MAPK12 wt Allele [NCIt concept]
- MAPK13 wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- MAPK3 wt Allele [NCIt concept]
- MAPK8 wt Allele [NCIt concept]
- MAPK9 wt Allele [NCIt concept]
- NFKB1 wt Allele [NCIt concept]
- NFKBIA wt Allele [NCIt concept]
- NOS2 wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CB wt Allele [NCIt concept]
- PIK3CD wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PIK3R2 wt Allele [NCIt concept]
- PIK3R3 wt Allele [NCIt concept]
- PIK3R5 wt Allele [NCIt concept]
- PLCB3 wt Allele [NCIt concept]
- PLCB4 wt Allele [NCIt concept]
- PPP2CA wt Allele [NCIt concept]
- PPP2CB wt Allele [NCIt concept]
- PPP2R1A wt Allele [NCIt concept]
- PPP2R2A wt Allele [NCIt concept]
- PPP2R2B wt Allele [NCIt concept]
- RELA wt Allele [NCIt concept]
- SMAD2 wt Allele [NCIt concept]
- SMAD3 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFB2 wt Allele [NCIt concept]
- TGFB3 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TICAM1 wt Allele [NCIt concept]
- TLR2 wt Allele [NCIt concept]
- TLR4 wt Allele [NCIt concept]
- TLR6 wt Allele [NCIt concept]
- TLR9 wt Allele [NCIt concept]
- TNF wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TRAF6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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