" /> Chagas Disease Pathway - CISMeF





Preferred Label : Chagas Disease Pathway;

NCIt synonyms : T. cruzi Infection Pathway; Trypanosoma cruzi Infection Pathway;

NCIt related terms : Chagas disease (American trypanosomiasis); Chagas disease;

Alternative definition : KEGG: Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2 signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.;

KEGG ID : hsa05142;

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28/07/2025


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