Angiotensin-Converting Enzyme

Preferred Label : Angiotensin-Converting Enzyme;

NCIt synonyms : Dipeptidyl Carboxypeptidase I; Dipeptidyl Carboxypeptidase 1; Carboxycathepsin; Kininase II; ACE; EC 3.4.15.1; EC 3.2.1.-; CD143 Antigen; CD143; Peptidase P; Peptidyl-Dipeptidase A; Testicular ECA; Angiotensin Converting Enzyme, Somatic Isoform;

NCIt definition : Angiotensin-converting enzyme (1306 aa, 150 kDa) is encoded by the human ACE gene. This protein plays a role in the hydrolysis of angiotensin I to form angiotensin II and the solubilization of glycophophoinositol-anchored proteins from the plasma membrane.;

NCIt note : Angiotensin-converting enzyme exhibits both peptidase and glycosidase activity.;

Détails

Origin ID

C91297;

UMLS CUI

C1452534;

Currated CISMeF NLP mapping
- Angiotensin I-converting enzyme [OMIM Phenotype]
- Angiotensin converting enzyme [MedDRA Preferred Term]
- Dipeptidyl carboxypeptidase I (substance) [SNOMED CT concept]
- Peptidyl-Dipeptidase A [MeSH Descriptor]
- Peptidyl-Dipeptidase A [MeSH concept]
- dipeptidyl carboxypeptidase i [SNOMED Notion]
False automatic mappings
- acyl protein synthetase [MeSH Supplementary Concept]
- carbon monoxide-methylene blue oxidoreductase [MeSH Supplementary Concept]
- chitotriosidase [MeSH Supplementary Concept]
- dextran alpha-(1-2)-debranching enzyme [MeSH Supplementary Concept]
- glycoside hydrolases [MeSH Descriptor]
- hydroxycinnamoyl-CoA anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase [MeSH Supplementary Concept]
- sialidase L [MeSH Supplementary Concept]
OMIM relation
- Angiotensin I-converting enzyme [OMIM Phenotype]
See also inter- (CISMeF)
- Angiotensin converting enzyme [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ACE protein, human [MeSH concept]
- ACE protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ACE Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Angiotensin-converting Enzyme 2 Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Hypertrophic Cardiomyopathy Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
- Vasodilation [NCIt concept]
is_target
- Benazepril Hydrochloride [NCIt concept]
- Lisinopril [NCIt concept]
- Ramipril [NCIt concept]

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