Toll-Like Receptor 4

Preferred Label : Toll-Like Receptor 4;

NCIt synonyms : Toll-Like Receptor-4; TLR4; TOLL; hToll; Toll Homolog; CD284 Antigen;

NCIt definition : Toll-like receptor 4 (839 aa, 96 kDa) is encoded by the human TLR4 gene. This protein is involved in regulation of both fatty acid-induced inflammation and the innate immune response following bacterial lipopolysaccharide binding.;

NCIt note : As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response.;

Details

Origin ID

C30105;

UMLS CUI

C1321919;

Currated CISMeF NLP mapping
- Toll-Like receptor 4 [MeSH concept]
- Toll-like receptor 4 [OMIM gene]
- toll-like receptor 4 [MeSH Descriptor]
OMIM relation
- Toll-like receptor 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TLR4 protein, human [MeSH concept]
- TLR4 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TLR4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Amoebiasis Pathway [NCIt concept]
- Beta-Catenin Accumulation Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Dendritic Cell Pathway [NCIt concept]
- Leishmaniasis Infection Pathway [NCIt concept]
- Malaria Pathway [NCIt concept]
- NFKB Signaling Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Salmonella Pathway [NCIt concept]
- Toll-Like Receptor Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Cultured Lentinula edodes Mycelia Extract [NCIt concept]
- Paridiprubart [NCIt concept]
- TLR4 Agonist G100 [NCIt concept]

Keyword's position in hierarchy(ies) :

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