TLR4 Agonist G100

Preferred Label : TLR4 Agonist G100;

NCIt synonyms : Glucopyranosyl Lipid Adjuvant-Stable Emulsion; Toll-like Receptor 4 Agonist GLA-SE; TLR 4 Agonist G100; Glucopyranosyl Lipid A Stable Emulsion; TLR-4 Agonist GLA-SE; Toll-like Receptor 4 Agonist G100; GLA-SE; TLR-4 Agonist G100;

NCIt definition : A synthetic lipid A derivative and selective toll-like receptor 4 (TLR4) agonist composed of glucopyranosyl lipid-A (GLA) in a stable, oil-in-water emulsion (GLA-SE), with potential immunostimulating and antineoplastic activities. Upon intratumoral administration into the immunosuppressed tumor microenvironment (TME), TLR4 agonist G100 binds to and activates TLR4 on various immune cells, thereby stimulating dendritic cells (DCs), monocytes and macrophages. This activation results in the production of pro-inflammatory cytokines and chemokines. This induces a T helper cell-1 (Th1) immune response and activates a cytotoxic T-lymphocyte (CTL) response against tumor-associated antigens (TAAs) that were released in the TME by tumor cells lysed during cytotoxic treatments, such as radiotherapy. TLR4, a member of the TLR family, plays a key role in the activation of innate immunity.;

Molecule name : G100;

NCI Metathesaurus CUI : CL458362;

Details

Origin ID

C113649;

UMLS CUI

C3827001;

Automatic exact mappings (from CISMeF team)
- TLR4 agonist G100 [MeSH Supplementary Concept]
- TLR4 agonist G100 [MeSH concept]
Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TLR4 agonist G100 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Toll-Like Receptor 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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