" /> Paridiprubart - CISMeF





Preferred Label : Paridiprubart;

NCIt synonyms : Anti-toll-like Receptor 4 Monoclonal Antibody EB05; Anti-TLR4 Monoclonal Antibody EB05;

NCIt definition : A monoclonal antibody directed against toll-like receptor 4 (TLR4), with potential anti-inflammatory activity. Upon administration, paridiprubart targets TLR4, blocks its receptor dimerization and inhibits TLR4 signaling, thereby inhibiting TLR4-mediated pro-inflammatory cytokine secretion and inflammatory response. This may reduce lung injury in acute respiratory distress syndrome (ARDS). TLR4, a member of the TLR family found on macrophages, dendritic cells (DCs) and other innate immune cells, is an important mediator of cytokine release and inflammatory response in viral infections.;

UNII : 4LH8QAS0LR;

CAS number : 2641646-59-3;

Molecule name : EB-05; EB 05; NI-0101;

NCI Metathesaurus CUI : CL1770955;

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Keyword's position in hierarchy(ies) : arborescence

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09/05/2025


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