NCIt definition : A monoclonal antibody directed against toll-like receptor 4 (TLR4), with potential
anti-inflammatory activity. Upon administration, paridiprubart targets TLR4, blocks
its receptor dimerization and inhibits TLR4 signaling, thereby inhibiting TLR4-mediated
pro-inflammatory cytokine secretion and inflammatory response. This may reduce lung
injury in acute respiratory distress syndrome (ARDS). TLR4, a member of the TLR family
found on macrophages, dendritic cells (DCs) and other innate immune cells, is an important
mediator of cytokine release and inflammatory response in viral infections.;
UNII : 4LH8QAS0LR;
CAS number : 2641646-59-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2641646-59-3
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