Preferred Label : Pathogenic Escherichia coli Infection Pathway;
NCIt synonyms : Pathogenic E. coli Infection Pathway;
NCIt related terms : Pathogenic Escherichia coli infection;
Alternative definition : KEGG: Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely
related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections
is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial
cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte
effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded
effector proteins secreted via the type III secretion system, which is also LEE-encoded,
into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell
cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization.
EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded
adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm,
where it is inserted into the outer membrane. In addition to Tir, two potential host
cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so
far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like
toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing
the intoxicated epithelial or endothelial cells.;
KEGG ID : hsa05130;
Origin ID : C91474;
UMLS CUI : C2984286;
- Semantic type(s)
- has_gene_product_element
- pathway_has_gene_element