Claudin-18 - CISMeF

Preferred Label : Claudin-18;

NCIt synonyms : Claudin 18 Isoform A1; Claudin 18 Isoform 1; CLDN18; Claudin 18; CLDN18.1; Claudin 18.1; Claudin-18 Isoform A1; Claudin-18 Isoform 1; Surfactant Associated Protein J; CLDN-18; CLDN-18.1;

CISMeF acronym : CLDN18;

NCIt definition : Claudin-18 (261 aa, 28 kDa) is encoded by the human CLDN18 gene. This protein plays a role in tight junction formation in the epithelium of the lung.;

NCIt note : Claudin-18 is predominantly expressed in normal lung epithelium. (Clin Cancer Res 2008;14:7624-7634); Uniprot considers isoform A1 the canonical form of the claudin-18 protein. The transcript for this isoform utilizes the start codon in exon 1a (1.1).;

NCI Metathesaurus CUI : CL552141;

Details

Origin ID

C150411;

UMLS CUI

C4724725;

Automatic exact mappings (from CISMeF team)
- Claudin 18 [OMIM gene]
- claudin 18 [HGNC gene]
OMIM relation
- Claudin 18 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CLDN18 Gene [NCIt concept]
- Cell Adhesion Molecule Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelium [NCIt concept]
- Lung [NCIt concept]
gene_product_has_associated_anatomy
- Epithelial Cell [NCIt concept]
- Plasma Membrane [NCIt concept]
- Tight Junction [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Cluster of Differentiation [NCIt concept]
gene_product_is_element_in_pathway
- Cell Adhesion Molecule Signaling Pathway [NCIt concept]
- Leukocyte Transendothelial Migration Pathway [NCIt concept]
- Pathogenic Escherichia coli Infection Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell-Cell Adhesion Process [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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